Injections

[TimDrake]

Hi! i have just now completed my second series of testicular injections. i am working with a nurse in Florida. The first series was dep-provera 150mgs into each testicle. It was very uncomfortable like for a week or so. This series was 5 mgs each of estradol long acting into each testicle. I ddint feel anything and it doesent hurt. The nurse said that it will still take some more injections but that to keep going and my testicles will die and shrivel up into nothing. YESSSS!!!!!!!!!! prncalexe Ps. I am looking for Chem-cast for purchase. Does anybody know where to get it?????? Please

[SplitDik]

Chem-Cast was never marketed -- it was retracted from the FDA approval process by the manufacturer. It is some people's opinion on this board that while it was effective at castration, it may have left traces of chemical in the meat of the animals (and therefore not meet food safety requirements).

Our research has shown that Chem-Cast's active ingredient was DL-Lactic Acid. In other words, it was just an injection of a weak organic acid. DL-lactic acid is available fairly widely through chemical supply stores, as it is used in food products.

Note: I don't think that injections of Depo-Provera will cause your balls to die. They will shrink while you are on Depo-Provera, but you will have to continue the injections regularly -- the effect is not permanent. The DL-Lactic Acid is permanent because it destroys the tissue.

The most promising thing is called Gonex, but is not available yet.

See: http://www.gonex.com/veterinary/index.htm

[TimDrake]

Now lets just say I purchase some DL-lactic acid. I put it into a syringe lets say a 1cc syringe and inject my testicles. Any idea of pain? Any idea of dose. I am 160lbs. small testicles. I most likely could inject more. Do u think i could get this a t a GNC. I know that whatever you say.... it's all on me!!!!! I just need your advise, you seem so knowledgeable. If this is a good way to discretly kill ones balls, how come more of us havent tried it? prncalexe. Please answer as soon as you can. please.

[SplitDik]

Well, you want to inject an amount that will "eat away" at the testicular tissue but not so much that it affects other parts of your body.

According to the ChemCast publicity, it was "painless" for the cows. This is because lactic acid has a pain numbing quality -- lactic acid is what gives you that numb feeling in your muscles if you've been weight training or exercising heavily.

I doubt it is fully painless, but I am sure it would not be much more painful than your current injections or other methods of destroying testicles.

In terms of amounts, I would start small. Apparently 1cc per testicle was recommended for cows. I doubt you're as big as a cow, so I would definitely start with 1/2 cc or less per.

It would be much worse to inject too much than to inject too little. Take your time.

[Jesus]

SplitDik is mostly right. ChemCast was pulled from the Canadian market after only about a year. The “official” problem was that with production line useage, not enough care was being taken to make certain that it was injected in the right location. ChemCast was on the market in the U.S. until the patent ran out and the company could no longer claim a premium price for a simple, readily available chemical. There are about FORTY THOUSAND TONS a year of lactic acid produced in the world for various industrial uses! Wholesale price is in the pennies per pound.

I’ve attached most of the U.S. patent application below (and you can read the entire patent on their site). Several other organic acids also seem to work, though lactic acid worked most consistently.
__________

United States Patent 4,356,189
Stagg , et al. October 26, 1982

Chemical castration

Abstract

The invention is a unique procedure for chemical sterilization of male animals by injection of a suitable solution into both spermatic cords to cause sterilization with loss of libido and spermatogenesis. Chemical agents which have been found effective include weak acids and weak bases, lactic acid being preferred. Secondly, the invention is a procedure for chemical
sterilization of male animals by injecting lactic acid directly into both testis causing both loss of spermatogenesis and libido. Thirdly, the invention is a procedure for chemical sterilization of male animals by injecting lactic acid into both caudel epididymis causing sterilization only.


Inventors: Stagg; Charles M. (St. Joseph, MO); Tribble; Ronald L. (Savannah, MO)
Assignee: Philips, Roxane, Inc. (St. Joseph, MO)
Appl. No.: 235326
Filed: February 17, 1981

Primary Examiner: Schenkman; Leonard
Attorney, Agent or Firm: Schmidt, Johnson, Hovey & Williams

Parent Case Text

This is a continuation of application Ser. No. 029,637, filed Apr. 13, 1979 and now abandoned.
Claims

What is claimed is:

1. A method of chemically castrating male mammals of the feline, canine, equine, bovine, ovine and porcine species of mammals comprising injecting into both testes or into both spermatic cords of said mammals a castratingly effective amount of lactic acid.

2. The method of claim 1 wherein the lactic acid is injected into both testes of the mammal.

3. The method of claim 1 wherein the lactic acid is injected into both spermatic cords and the mammal is a member of the bovine, canine, or ovine species.

4. The method of claim 1 wherein the mammal chemically castrated is a bull.

5. The method of claim 4 wherein an aqueous solution of lactic acid is employed.

6. The method of claim 5 wherein the lactic acid is injected into both testes of the bull.

7. The method of claim 5 wherein the lactic acid is injected into both spermatic cords of the bull.

8. The method of claim 5 wherein the bull weighs less than 500 pounds.

9. The method of claim 5 wherein an 85% concentration of lactic acid is employed.

10. The method of claim 1 wherein the mammal chemically castrated is a dog.

Description

This invention relates to a novel method for the sterilization of male animals and more particularly, relates to a method for chemical castration and chemical contraception of males which is simple, effective and has no undesirable side effects. The method by which chemical castration is accomplished is by injection of an appropriate composition into both
spermatic cords or directly into both testes thereby causing atrophy of both testes. A method for chemical contraception without atrophy of testes is accomplished by injecting an appropriate composition into both caudel epididymis. These methods can be used on all kinds of male animals having external testes including domestic animals, farm animals, and exotic or zoo
animals. More specifically, the methods comprise injecting aqueous lactic acid into the preferred site.

Many attempts have been made in the past to carry out successfully the sterilization of male animals by chemical means. A variety of chemical agents and mixtures both natural and synthetic have been studied and tested for their ability to render male animals unable to produce off-spring. Also, past efforts to effect such castrations have included various approaches to introducing the selected agents into the male reproductive organs. As examples, certain sclerotic agents have been injected into the caudel epididymis or vas deferens in order to interfere with the passage of live sperm from the testes to the exterior. Tests have also been carried out using various agents for injection into the testes themselves. These methods
have been found to have a number of disadvantages such as lack of desired efficacy and/or failure to prevent libido and/or cause uncontrollable necrotic tissue damage.

It has long been possible to castrate male animals by surgical means. Surgical castration involves an open incision, which often results in infections, excessive bleeding, fly infestation and tetanus which can lead to death. Surgical procedures are well known to cause excessive stress in most animals and are never without pain.

The testes of the male animal perform two major functions. One is for spermatogenesis which originates in the seminiferous tubules, and the second is for the production of androgens (testosterone and dihydrotestosterone) which arise from the interstitual cells (Leydig cells). The sperm cells after their production within the testes are liberated into the head of the epididymis and travel to the tail of the epididymis. The tail of the epididymis (caudel epididymis) is made up of a cavernous network of convoluted tubules. The function of the epididymis is for transport, maturation, concentration, and storage of sperm. Upon ejaculation, sperm cells are liberated from the caudel epididymis into the vas deferens and eventually through the penis to the exterior. The function of both spermatic cords is to provide nutrient, gas exchange, and thermo-regulation for the testes by way of the pampiniform plexus vascular system.

It is a unique and essential feature of the invention that the agent be administered into both spermatic cords resulting in complete disruption of the vascular system thus causing testicular atrophy with loss of both spermatogenesis and libido.

Another feature of the invention is to inject lactic acid into both testes resulting in testes atrophy with loss of libido and spermatogenesis or inject into both caudel epididymis resulting in sterilization (contraception) without loss of libido.

The injecting substance which has been found to be most effective is a lactic acid solution. In any event, it is considered most effective to use an aqueous solution. Of particular usefulness is a lactic acid solution which should be U.S.P. grade or better. One such product is a mixture of lactic acid and lactic acid lactate which is equivalent to a total of not less than 85% and more than 90% by weight of lactic acid (U.S.P. grade).

Other materials which can be used for the injection method include acetic acid, acetic anhydride, propionic acid, butyric acid, succinic acid and the like. Lactic acid has been found to be dose related, which is a definite advantage over many other agents.

The chemical castration can be used for feline, canine, equine, bovine, ovine, and procine species of mammals. Specifically, the method is very successful and practical for bulls and male dogs. Injections made into boars, stallions, and male cats are less successful, primarily due to anatomical orientation and proportions of the male genitalia. Among mammalian species which could be successfully treated are those with pendulous type testis, such as male sheep and goats.

Among the limitations on the procedure are size and abnormal genitalia of the male to be chemically castrated. Thus, for more predictable and positive results, the treatment of the bull should be before his weight reaches about 500 pounds. With the dog, treatment of pups is not recommended.

The results of the procedure of the invention is atrophy of the testes by the preferred spermatic cord injections and secondly by intra-testis injections in small bulls causing ultimate loss of both libido and spermatogenesis; thirdly, injections of the caudel epididymis for chemical contraception without loss of libido.

Although it is necessary that veterinarians and others using the invention method have some procedural training, it has been found that a single demonstration or an explanation and/or an insert illustration are entirely adequate.

The invention procedure has been found to provide safe, rapid, economical and practical techniques for castration of animals. More rapid administration of the treatment is possible as compared to surgical castration. All the complications associated with surgical castration procedures are non-existent. Thus, it is safer, more humane, cleaner, and a great deal more convenient in every way than surgical castration.

It is also believed that this procedure of chemical castration may well yield greater performance results, that is for instance, showing increased feed efficiency and rate of weight gain in bulls. Generally, surgical castration has been found to set an animal back in growth at least two weeks. In connection with bulls, it becomes important to understand that chemically castrated bulls are, in reality and every way, steers and not bulls. With respect to bulls weighing in excess of 500
pounds, the situation is no different than for the emasculated or crimped animal. Thus, the larger chemically castrated bulls generally will be found to have non-functional testes remaining as their feeding time is too short to allow the testes to atrophy completely. In bulls weighing less than 500 pounds the animals will probably have no testes and at the time of slaughter, the
scrotum will be shrunk.

The method has been shown to be versatile in its application and can be modified for various animals as required. For example, the volume and size of needle, as well as administration placement, can readily be modified for various animal species.

It is further to be noted, and the data obtained on animals has shown this, that lactic acid solution is preferred. It causes few side effects and is consistent in its effects. It is a normal, naturally occurring biological chemical and is therefore safe and predictable. It is, of course, also easy to assay in tissue samples and residues.

More specifically, in testing the chemical castration procedure, concentrations of lactic acid of from 5 to 85% in aqueous solution and from 0.25 to 16 mls. have been tested with success on bulls and male dogs and with limited success in stallions and boars.

The injection site of choice is both spermatic cords. The advantage of this site over intra-testes injections is that one needs only to cause damage to a relatively small area in contrast to the whole testis. However, in small calves (less than 100 lbs) the choice would be the testes injections as the testis is easier to inject and there is not much tissue at this size to destroy.
The caudel epididymis injection procedure has the disadvantage of not eliminating libido; however, when a near intact male is desired, this may be the recommended choice such as for those male dog owners wanting a sterile masculine appearing dog and for those cattle owners desiring bulls for heat checking their cows without the risk of getting them bred to an unwanted male.

The invention technique developed for castration of male animals has wide application. This chemical castration has been employed for example, quite satisfactorily with bulls and male dogs. It has been found to be less useful for castration of male cats, pigs and stallions.

With respect to use of the method for bulls, there are approximately fifty to sixty million calves born in the United States each year of which approximately 50% are bull calves; there are potentially twenty to thirty million bull calves, most of which ordinarily undergo castration.

As for dogs, the method of the invention has great usefulness as a safe, rapid and economical method to produce male sterility as an aid in curbing the dog population. There is great need for an economical male sterilizing procedure in animal shelters and in areas where a differential dog license fee scale exists.

The first object of the experimentation was to determine the ease of administration of a chemical agent in several domestic male mammalian species. The use of Giemsa stain and lactic acid was used to determine both physical limitations and area of ensuing damage subsequent to administration. Three possible injection sites were explored, i.e., the spermatic cord, the testis, and the caudel epididymis.

It was found that a sound administrative approach for male dogs was both the caudel epididymis and spermatic cords and for bulls the spermatic cords and testes. It must be noted that caudel epididymis injections were not performed for the bull; however, this site of injection should be easy to administer the chemical agent.

It is very difficult to inject male cats and boars by either the caudel epididymis and spermatic cord approach due to the physical characteristics and orientation of the male genitalia. Administration approaches for rams have not been tested; however, no problems would be anticipated as their genitalia is of the same nature as for the bull.

It has been found that spermatic cord injections in the stallion presented no problem as to ease of administration; however, for reasons unexplainable at this time, the desired efficacy was lacking. Forty-nine injections were made into spermatic cords using various concentrations and volumes of lactic acid. Only nine successes were accomplished and these were not dose dependent.

The invention will be further described and defined by the following Examples, although it is in no way intended to limit the invention thereto .

EXAMPLE 1

A total of 173 bulls ranging in weight from 100 to 635 pounds were studied using both varying concentrations and varying volumes of lactic acid containing agent injected into both spermatic cords. An additional four bulls were emasculated to serve as positive controls. Thirty-seven of the 173 bulls injected weighed in excess of 500 pounds. The results of these studies are
shown in Tables I and II below. Qualitatively, it was found that better results are obtained when the invention procedure is used on bulls weighing less than 500 pounds.

It was found that the lactic acid was dose-dependent on body weight. From the results in Tables I and II, it was found that the recommended dosage of 85% lactic acid for various weights is as follows:

______________________________________
Minimum Effective Dosage
Body Weight Range
. . Percent
(ml) (lbs.) Efficacy
______________________________________
2 200 or less 93
4 200 to 300 100
8 300 to 500 82
______________________________________
TABLE I

[madscientist]

RE: Intra-testicular Depo-Provera. Prncalexe, I do not know why you are taking DP in the testes. If you wish to control your libido then the intra-muscular route can be employed, preferably into a large muscle mass like the gluteus maximus, located in the upper, outer quarter of the buttock.
RE: Chem-Cast. It appears that a good dose for humans would be 4ml per testicle, if you want to ensure castration on the first try. It also appears that injection into the spermatic cord rather than the testicle will produce the desired effect. This will, of course, be less painful, though the cord may have to be clamped to prevent leakage into the urethra.
One possible source of lactic acid is http://www.citychemical.com. I have ordered from them in the past, but that was some time ago. Try & see.

[SplitDik]

Jesus,

That is excellent info on the subject. Thank you.

It seems like a very good candidate for human castration. Who will be the first to try it out I wonder?

Somebody should archive Jesus' post, because it contains very good information that would be a shame to lose within the message board.

[Scottie]

Hi my user name was prncalexe until the server would not allow me in. So now it is Scottie. So forgive me. I have been trying to get in for 2 weeks and now finally i have.
Here is what is going on. I finally got a hold of Lactic acid 100% solution. I injected 1ml into each testicle. It hurt like hell, and I could feel the vas burnning. I left my office and had to go home not to pass out. The next day my testicles where very very swollen. Not to much pain but huge testicles. I iced them and eventually had to go to see a Doc, becasue I was afraid. I told him a story on how 2 pro`Dommes did this to me. Now here is what is happening. My testicles are still very large and very very hard. I don't know if the swelling will ever leave??? Does anyone know????? Or what I can do to get the swelling gone????? I am going for an ultra sound. and then a testosterone test. I have to play along if I dont want to be committed. IF ANYONE ANYONE OUT THERE HAS ANY ADVISE, ON SWELLING, WHAT I SHOULD DO ABOUT THE DOC, THE BLOOD TESTS OR THE ULTRA SOUND PLEASE WRITE SOON. PLEASE I BEG YOU ALL WITH GREATER KNOWLEDGE THAN ME TO HELP!!!!!! Scottie allias prncalexe

[Sage]

Wow,

Hate to point this out cause it may be too late but there were lots of posts on this forum about injecting lactic acid directly into the testicles earlier this year. The general concensus was that it hurt like hell and caused serious medical problems. I suggest doing some searches on the subject and read about what others have done before you proceed.

Hope this helps

Sage

[Paolo]

This thread is over 4 years old, and we've since had quite the go-round about testicular injections with lactic acid, etc. Especially Scottie. I think the general opinion was, as Scottie once put it, "a big mistake." (and that's probably an understatement.)

It's also not a good idea to start all of this talk again in such an old thread. I'll see if I can search up the link to Scottie's "adventure".

Here's one:
http://www.eunuch.org/vbulletin/show...ht=lactic+acid

Here's another:
http://www.eunuch.org/vbulletin/showthread.php?p=46286

Thread now closed.

[Jesus]

For a very detailed and incredibly painful even to read first person account of the use of Chem-Cast on a human, read Scottie’s story on the thread Consequences of Castration, posts number 23 through 26. It should be enough to keep any sane person from ever contemplating its use!